MYC and adult T-cell leukemia/lymphoma: In 2018, Romeo et al. [86] demonstrated that HTLV-1-transformed T-cell-lines (MJG11, SLB1, ATL-1, and ATL-7) and primary uncultured HTLV-1-infected ATLL clinical samples contain elevated levels of TIGAR that correlated with oncogenic c-Myc expression as compared to activated hu-PBMCs.