CD8A and tropical spastic paraparesis: Further, Pique et al. [91] have isolated CD8+ cytotoxic T-lymphocytes (CTLs) that specifically target the ORF-II p30II and p13II peptides from HTLV-1-infected carriers, HAM/TSP and ATLL patients, suggesting these proteins are chronically expressed and could contribute to the establishment of persistent infections in vivo as well as viral pathogenesis.