Using a highly-penetrant NOD/scid xenograft model of HTLV-1-induced T-cell lymphoma, Hutchison et al. [53] demonstrated that TIGAR is expressed at high levels in engrafted HTLV-1-infected SLB1 or Met-1 tumor lymphocytes, associated with c-Myc dysregulation in the primary tumor masses and infiltrated secondary tissues. Here, TIGAR is linked to T-cell non-Hodgkin lymphoma.