Notably, a recent study indicated that cleavage of gasdermin E (GSDME) by caspase-3 induced pyroptosis in neuroblastoma and melanoma cells following treatment with chemotherapeutic agents, such as DNA-binding/modifying compounds (doxorubicin, cisplatin and actinomycin-D) and the topoisomerase inhibitors (topotecan, CPT-11, etoposide and mitoxantrone) [17]. The gene discussed is GSDME; the disease is melanoma.