We also demonstrated that α7-nAChR’s oncogenic role is mediated in part by JAK2 activation and that the α7-nAChR promotes recurrence of human HCC by forming α7-nAChR/JAK2 complex and modulating the downstream TGR5/JAK2/STAT3 signaling axis (Figure 5). This evidence concerns the gene STAT3 and hepatocellular carcinoma.