The α7-nAChR was significantly overexpressed in HCC specimens (n = 38) compared to non-tumor liver specimens (n = 19) (~2-fold increase, p = 0.002); this was similar to that of JAK2 (~2-fold increase, p = 2.89 × 10−9) (Figure 4B). This evidence concerns the gene JAK2 and hepatocellular carcinoma.