Beyond neuronal cells, there is convergent evidence that exposure to smoking or nicotine increases α7-nAChR levels in non-neuronal cells such as normal lung epithelial cells, keratinocytes, monocytes, pancreatic ductal adenocarcinoma (PDAC) cells, and human squamous cell lung cancer cells [32,33]. The gene discussed is CHRNA7; the disease is squamous cell lung carcinoma.