Of note, none of the cytobands identified as significantly altered in both R and fS class of R0 patients at gene level is comprised in the recurrent chromosomal aberrations identified and only 5 genes (FAS, HEY1, SH2B3, TBX3, USP44) were included in the COSMIC (Catalogue of Somatic Mutations in Cancer) Cancer Gene Census list, suggesting that new information can be acquired with this approach. Here, HEY1 is linked to cancer.