We further found that the QC-mediated inhibition of Nrf2 sensitizes CRC cells to 5-FU, which has been widely used in the treatment of breast, gastric and pancreatic cancers, as well as squamous cell carcinomas arising in the head and neck [8] under hypoxic conditions (Figure 1 and Figure 2). The gene discussed is NFE2L2; the disease is squamous cell carcinoma.