To determine whether QC affects the mRNA stability of Nrf2 in CRC cells, we treated HCT116 and RKO cells with 5 μM QC under normoxia or hypoxia for 4 h in the presence of 5 μg/mL actinomycin D, which blocks de novo mRNA synthesis. Here, NFE2L2 is linked to colorectal carcinoma.