SOD1 and gastric cancer: Firstly, for rats having N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer, lycopene reduced oxidative injury to gastric tissues by decreasing the level of the oxidative parameter (malondialdehyde) and increased activities of antioxidant enzymes (SOD, catalase, and glutathione peroxidase) [41].