SPP1 and neoplasm: Tumor-associated macrophages play a leading role in tumor growth, angiogenesis, metastasis due to the production of a large number of growth factors: PDGFβ, VEGF, TGFβ, and EGFR ligands, cytokines: IL-6, TNFα, and IL-10, chemokines: CCL17, CCL22, CCL24, CXCL12, and IL-8, as well as other factors (MMPs, osteopontin, and cyclooxyganse-2) [122,123].