Recently, Bache et al., demonstrated an upregulation of GLUT1 mRNA expression in glioblastoma, proposing this along with other proteins, including hypoxia-inducible factor-1a (HIF-1a), VEGF and OCT4, as a marker of hypoxia-induced changes that define the metabolism of GBM [46]. This evidence concerns the gene VEGFA and glioblastoma.