Second, we focused on only the genetic risk factors PXR and NF-κB1; the examination of other relevant genes, environmental risks, comorbid conditions (malnutrition, alcoholism, chronic hepatitis C and chronic hepatitis B infection, HIV infection and pre-existing liver disease) and epigenetic modifications is necessary to improve the accuracy and reliability of the study. Here, NFKB1 is linked to chronic hepatitis C virus infection.