TRIM27 and cancer: While, four hypermethylated CpG sites in early stage (cg18578954, cg07402003 cg16657244, cg06176471) are associated with TRIM27, TOX3, NOLC1, and ATP1B1. In the literature, it has been shown that these genes are epigenetically regulated and associated with cancer progression in different malignancies [57–63].