In the tissue, eosinophils can release toxic granule contents including Major Basic Protein (MBP), Eosinophil Derived Neurotoxin (EDN), and Eosinophil Peroxidase (EPX), which may cause intended damage to the target in the case of parasitic infections, but can inadvertently damage surrounding host tissue and trigger remodeling. This evidence concerns the gene RNASE2 and parasitic infectious disease.