In the tissue, eosinophils can release toxic granule contents including Major Basic Protein (MBP), Eosinophil Derived Neurotoxin (EDN), and Eosinophil Peroxidase (EPX), which may cause intended damage to the target in the case of parasitic infections, but can inadvertently damage surrounding host tissue and trigger remodeling. The gene discussed is EPX; the disease is parasitic infectious disease.