PLN and familial dilated cardiomyopathy: For example, dilated cardiomyopathy (DCM), which is defined by systolic dysfunction and dilation of one or both ventricles, can be caused in humans by mutations in the genes encoding cardiac phospholamban (PLN), delta-sarcoglycan (SGCD), and RNA-binding protein 20 (RBM20) [49, 50].