For example, we find a similar set of correlations for atrioventricular septal disease (AVSD) [51], which in human is caused by mutations in CRELD1 (enriched in pig), Gap junction alpha-1 (GJA1) and transcription factor GATA-4 (GATA4) (enriched in mouse and pig), and GATA6 (enriched in X. laevis). The gene discussed is GATA4; the disease is familial atrioventricular septal defect.