In a recent meta‐analysis, both positive membranous and cytoplasmic IGF‐1R protein levels were reported as a favorable prognostic factor for overall and breast cancer‐specific survival in patients with hormone receptor‐positive breast cancer.33 In the study of Bjorner et al.,34 positive p‐IGF‐1R/InsR staining was associated with a lower risk for events among non‐endocrine‐treated patients, irrespective of ER status. The gene discussed is ESR1; the disease is breast cancer.