Laboratory data revealed the following: extremely high plasma glucose levels, 989 mg/dL (54.9 mmol/L); presence of urinary ketone bodies; blood pH, 6.85; and bicarbonate level, 2.4 mmol/L; these findings met the diagnostic criteria for DKA proposed by the American Diabetes Association.[5] Fasting serum C-peptide immunoreactivity (CPR) was 0.62 ng/mL and urinary CPR was 13.4 μg/d, indicating deterioration of endogenous insulin secretion. This evidence concerns the gene INS and diabetes mellitus.