The Gadd45gip1/Gadd45γ pathway is involved in tumor recurrence as a downstream pathway of NAC‐1.17, 18 To investigate whether CRM197 reverses resistance to paclitaxel via the Gadd45gip1/Gadd45γ pathway, we examined the effect of CRM197 on the expression of Gadd45gip1/Gadd45γ in parental (A2780 and SKOV3) and paclitaxel‐resistant (A2780/Taxol and SKOV3/Taxol) ovarian cancer cells by western blotting. This evidence concerns the gene GADD45G and ovarian carcinoma.