First, we investigated the role of nucleus accumbens‐1 (NAC‐1) and its downstream pathway, growth arrest and DNA damage‐inducible 45‐γ interacting protein (Gadd45gip1)/growth arrest and DNA damage‐inducible 45 (Gadd45), in CRM197‐mediated reversal of paclitaxel resistance in ovarian cancer cells. The gene discussed is GADD45GIP1; the disease is ovarian carcinoma.