Heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is one of the seven ligands of the epidermal growth factor receptor (EGFR) and the primary EGFR ligand altered in ovarian cancer.3, 4 HB‐EGF plays a critical role in proliferation, angiogenesis, and metastasis of ovarian cancer, making it a putative therapeutic target for ovarian cancer. The gene discussed is EGFR; the disease is ovarian cancer.