In this study, we analyzed the mechanism of reversion of paclitaxel resistance by CRM197 and identified a signaling axis involving NAC‐1/Gadd45gip1/Gadd45γ, which appears to enhance activities of the proapoptotic JNK/p38MAPK pathway that induces paclitaxel resistance in ovarian cancer. Here, GADD45GIP1 is linked to ovarian cancer.