IRAK4 and pancreatic neoplasm: For example, the low expression of CHD5 could activate DNA damage response and function as useful biomarker for pancreatic cancer poor clinical outcome.76 Similarly, phosphorylation status of IRAK4 was a predictor for postoperative relapse and poor overall survival in patient with PDAC.77 Upregulation of CIAPIN1 could delay cell cycle progression and induce cell apoptosis.