For example, the low expression of CHD5 could activate DNA damage response and function as useful biomarker for pancreatic cancer poor clinical outcome.76 Similarly, phosphorylation status of IRAK4 was a predictor for postoperative relapse and poor overall survival in patient with PDAC.77 Upregulation of CIAPIN1 could delay cell cycle progression and induce cell apoptosis. Here, CIAPIN1 is linked to familial pancreatic carcinoma.