Besides, recent studies have found that CT gene also harbors a cancer‐promoting effect.10, 40 Therefore, accumulating articles believe oncogenic role of CT gene could be an ideal window of targeted therapy for tumors.41 For example, LIN28B, a newly defined CT gene, participated in the LIN28B/let‐7 axis that could be used to target MYC in multiple myeloma or other MYC‐dependent cancers.42 Besides, therapies targeting the classic CT gene MAGE‐A have already been put into clinical trail.43, 44 At present, the treatment of HCC, especially advanced HCC, faces great challenges. Here, LIN28B is linked to cancer.