The downregulation of PLK4 is able to inhibit the process of epithelial‐mesenchymal transition (EMT) both in vivo and in vitro, which is related to cancer metastasis.39 Therefore, the overexpression of PLK4 in HCC that we have found reveals its oncogenic role in promoting the generation of aneuploidy and cancer metastasis. The gene discussed is PLK4; the disease is cancer.