Here, we showed that dietary-induced obese animals supplemented with melatonin presented a significant reduction in fasting glycemia, indicating again the beneficial action of melatonin on glucose homeostasis, Corroborating these data, other studies employing pinealectomized animals have presented a significant reduction in the expression of the glucose transporter (GLUT 4), as well as glucose intolerance and insulin resistance, which were reverted by melatonin treatment [16,37]. Here, SLC2A4 is linked to Glucose intolerance.