According to pathological T-stage classification, we found that although TREM2 protein levels were heterogeneous in T3- and T4-stage samples, TREM2 levels in intensity 1 group were increased to 40%, 49% and 63% in T2-, T3- and T4-stage human colon carcinoma tissues, respectively (Figure 6C). The gene discussed is TREM2; the disease is colon carcinoma.