Several reports have shown that branched-chain aminoacids (BCAA), involving leucine, isoleucine, and valine have elevated levels in insulin-resistant and type 2 diabetic and obese patients body fluids (plasma and urine), therefore making them promising candidates as risk predicting biomarkers for type 2 diabetes [104,105,106], in the first four years. The gene discussed is INS; the disease is type 2 diabetes mellitus.