SMPD1 and cancer: To investigate whether aSMase could be a specific target of GM in cancer cells, the experiment was repeated by incubating normal cells such as thyrocytes (FRTL-5), embryonic hippocampal cells (HN9.10), and lymphocytes, and other cancer cells as and lymphoma cells (SUP-T1) and hepatoma cells (H35), with 1.5 mM GM for 24 h.