FCGR2B and acute disseminated encephalomyelitis: FcγRII has two subsets that play different roles in ADE by either activating or inhibiting the process, particularly FcγRIIA which enhances ADE and FcγRIIB which abolishes ADE and both these molecules are known to be expressed in ADE supporting cells- monocytes, macrophage and moDC (mature and immature) [7,20].