Carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCAg), CYFRA21‐1, and neuron‐specific enolase (NSE) served as the serum tumor markers have been widely used for the routine examination of NSCLC patients.6 In this study, we investigated the predictive value of tumor markers (CEA, SCCAg, CYFRA21‐1, and NSE) in the prediction of ALK rearrangements. This evidence concerns the gene ENO2 and neoplasm.