A previous study showed that reduced miR‐214‐3p expression may contribute to MEF2C expression in myocardial hypertrophy.60 Some studies have shown that circulating miR‐22‐3p contains important information about chronic heart failure patients61 and participates in regulating the expression of hypertension‐related genes and in the development of hypertension.62 In our research, we excluded patients with heart failure, and circulating miR‐22‐3p was significantly upregulated in CAD patients compared with NCA controls. This evidence concerns the gene MEF2C and heart failure.