Compared with CRP, PTX3, produced only by the liver, is secreted by different cell types corresponding to infection, pro‐inflammatory stimulation and endotoxemia.22, 23, 24 Dias et al showed that PTX3 transgenic mice were more resistant to sepsis.25 Our study revealed that plasma PTX3 levels could be used to evaluate sepsis and septic shock on the first day of sepsis onset. Here, PTX3 is linked to serum lipopolysaccharide activity.