TEK and Sepsis: The endothelial‐specific angiopoietin (Ang)‐tyrosine kinase (Tie) system has been considered as an important mechanism in regulating endothelial activation of sepsis and as a possible determinant of injury severity.18 Angiopoietin 1 (Ang1) is released by pericytes, and it enhances the stability of formed vessels by binding to its receptor Tie2 in endothelial cells.19 Ang2 is stored in Weibel‐Palade bodies in endothelial cells.