The endothelial‐specific angiopoietin (Ang)‐tyrosine kinase (Tie) system has been considered as an important mechanism in regulating endothelial activation of sepsis and as a possible determinant of injury severity.18 Angiopoietin 1 (Ang1) is released by pericytes, and it enhances the stability of formed vessels by binding to its receptor Tie2 in endothelial cells.19 Ang2 is stored in Weibel‐Palade bodies in endothelial cells. Here, ANGPT1 is linked to Sepsis.