PARP1 and prostate cancer: 2015). Therefore, we examined the function of KAT5 in prostate cancer cells. Ectopic KAT5 expression enhanced the expression of proapoptotic proteins including Bax, cleaved caspase-3, cytosolic cytochrome c, and PARP, thus increasing the early and late apoptotic populations of prostate cancer cells (Figure 3). Our results clearly demonstrated that endogenous KAT5 levels are reduced in aggressive prostate cancer tissue (Human Protein Atlas data and Oncomine database; Figure 1).