TNF and cancer: 2016). The level of PRDX6 was lower in hepatocellular carcinoma, and its lower expression was an independent risk factor of poor prognosis. When the cancer cells were treated with H2O2, PRDX6 inhibited the apoptosis, however when treated with TNF-α, PRDX6 promoted the cell apoptosis (Xu et al. 2016).