Cancers are a very heterogeneous mixture of cells with distinct morphologies and phenotypes, such as intertumor and intratumor heterogeneity of HLA‐G expression, which has been addressed in a variety of cancers.2 Given that HLA‐G is a potent immune suppressor, in addition to directly inhibiting the function of immune effectors, the intercellular transfer of HLA‐G among tumor cells and immune cells extends its immune‐suppressive functions to a much broader spectrum. This evidence concerns the gene HLA-G and cancer.