In the context of cancers, the first evidence for an HLA‐G1 isoform transported through EVs in vitro was found in the supernatants of an HLA‐G1+ melanoma cell line (Fon) and an HLA‐G1‐transfected melanoma cell line (M8‐HLA‐G1).50 In clinical settings, a larger ubiquitinated HLA‐G complex with a higher molecular weight (50–150 kD) was found in exosomes from cancer patient ascites and pleural exudates in vivo. Here, HLA-G is linked to melanoma.