HLA-G and melanoma: For NK cells, the IL‐2‐activated NK cell line NKL can acquire HLA‐G1 from an HLA‐G‐transfected melanoma cell line (M8‐HLA‐G1).39 Consequently, the proliferation and cytolytic capability of the NKL‐HLA‐G1acq+ cells was dramatically impaired, and the NKL‐HLA‐G1acq+ cells became suppressive NK cells.