Indeed, a large body of research has reported that intercellular exchange of membrane proteins such as HLA‐G molecules occurs not only between tumor cells and immune cells but also between tumor cells and tumor cells.28, 29, 30 Consequently, the multidirectional exchange of HLA‐G can lead to functional interference of both immune cells and tumor cells.2, 11 Herein, we focus on the very aspects of the intercellular transfer of tumor cell‐derived HLA‐G by mechanisms such as trogocytosis, exosomes and nanotubes in tumor immune regulation (Figure 1). Here, HLA-G is linked to neoplasm.