HLA-G and neoplasm: Given the various mechanisms of HLA‐G in tumor immune evasion, multiple levels of HLA‐G‐based therapeutic strategies should be considered, such as inhibition of the intercellular transfer of HLA‐G, down‐regulation of HLA‐G expression, blockade of the HLA‐G and receptor interaction and application of tumor cell‐expressed HLA‐G as a target to develop drug delivery systems (Figure 2).