In the context of tumor immunology, HLA‐G can comprehensively impair host antitumor immune responses in multiple direct or indirect pathways.10 With the engagement of inhibitory receptors, HLA‐G expressed by malignant cells can directly impair the functions of different immune effectors such as NK cells, T cells, B cells, neutrophils, macrophages and dendritic cells (DCs). Here, HLA-G is linked to neoplasm.