First, through intercellular transfer, HLA‐G− tumor cells can uptake HLA‐G molecules from adjacent HLA‐G+ tumor cells in a cell‐to‐cell contact‐dependent manner by trogocytosis, and TnTs transfer or can uptake the HLA‐G antigen derived from distant HLA‐G+ tumor cells carried by exosomes. This evidence concerns the gene HLA-G and neoplasm.