In summary, this report highlights the biologic significance of neurotensin in FL-HCC by serving two important functions: 1) NTS provides a source of cAMP to stimulate PKA activity in the initiated tumor cells, and 2) acting through NTSR1, NTS potentiates cell growth and proliferation through the EGFR pathway. The gene discussed is NTSR1; the disease is hepatocellular carcinoma.