Group 1 also identified two genes with known pro-oncogenic roles without prior association with SS: CDCA7, and CRNDE. CDCA7 overexpression has been linked to progression of chronic myelogenous leukemia to blast crisis [41], and its encoded protein, JPO1, is a direct target of c-myc [42]. This evidence concerns the gene CDCA7 and chronic myelogenous leukemia, BCR-ABL1 positive.