This relationship between weight and hypertension could be related to the high risk of overweight patients for developing arterial stiffness and endothelial dysfunction which increases blood pressure by rising renal tubular reabsorption, impairing pressure natriuretic, and causing volume expansion due to activation of the sympathetic nervous system and renin-angiotensin-aldosterone system and by physical compression of the kidneys. Here, REN is linked to endothelial dysfunction.