AFP and hepatocellular carcinoma: However, these tests have been shown to be suboptimum for routine monitor of HCC, and the most widely used tumor marker AFP is not secreted in all hepatocellular carcinomas.5 Though serum AFP at a cutoff of 20 ng/mL has a sensitivity of 40–65% for clinically diagnosed HCC, only 14–40% of them are with preclinical disease.6 Similar to AFP-L3, the specificity and sensitivity of DCP for HCC diagnosis ranges from 36% to 96% and 89% to 94%.6