Different studies have reported that factor V Leiden and prothrombin gene mutations are effective in the development of RVO.6 Among these, factor V Leiden mutation is the genetic factor that causes thrombosis most frequently.22 This mutation is seen in white race in the frequency of 5%.22 When this mutation occurs, protein C becomes resistance to enzymatic degradation and causes hypercoagulability. Here, F5 is linked to thrombophilia.