ACE and Anxiety: Non-smoking patients had higher frequency of anxiety, as did those taking antihypertensives,1 but the relationship with polypharmacy that has previously been suggested was ruled out.36 There was no statistical significance to the association between anxiety and the drug classes taken routinely by patients, such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, diuretics, beta blockers, calcium channel blockers, and alpha 2 agonists.