Of the previously reported variants associated with endometriosis, most had the directionally concordant effect except for rs1250241, chr2:g.216 295312 T > A at 2q35, FN1, rs517875, chr3:g.174350886 C > A at 3q13, RAP1BP2, and rs13271465, chr8:g.17282411 T > C at 8p22, MTMR7/ADAM24P. The gene discussed is RAP1BP2; the disease is endometriosis.