In contrast, CD4 + T cells are less well defined as a prognostic marker in CRC, and few studies have reported a significant association between CD4 + T-cell density and survival.21,22 In addition, currently, forkhead box P3 (FOXP3) + cells are generally considered to be immunosuppressive in many types of cancers,23,24 with the exception of CRC, in which investigations of FOXP3 + cell infiltration have shown conflicting results.25,26. This evidence concerns the gene FOXP3 and colorectal carcinoma.