However, when we compared the degree of colon shortening in colitis-induced mice by analysing the change in colon lengths in colitis-induced vs water control mice results showed that colitis-induced Flii+/− mice have reduced percentage of colon shortening compared to wild-type counterparts while FliiTg/Tg mice had significant increase in percentage of colon shortening compared to both Flii+/− and wild-type counterparts suggestive of greater disease severity in response to higher levels of Flii (Fig. 2B). This evidence concerns the gene FLII and colitis.