Decreased colocalization between synaptophysin (SYP, a pre-synaptic marker) and Homer-1 (a post-synaptic marker) immunoreactive puncta, a measure of synaptic density, was observed in hippocampal CA3 region (Fig. 3g–k) and dentate gyrus (DG) (Supplementary Fig. 5a–e) of ZIKV-infected mice at 6 dpi, indicating that infection led to synapse damage and elimination. The gene discussed is HOMER1; the disease is infection.