Furthermore, Il36rn−/− mice were found to have significantly improved glucose tolerance and lower insulin resistance at 10 months of age over their wt counterparts (Fig. 2d–g), demonstrating that loss of expression of the IL-36 receptor antagonist leads to a decrease in normal weight gain and the spontaneous development of glucose intolerance observed in aged mice. The gene discussed is IL1RL2; the disease is Insulin resistance.