In an effort to explore mechanistically how the IL-36 family might regulate obesity and metabolic disease, we investigated what role, if any, these cytokines might play in disease pathogenesis in mice with a deficiency in the IL-36 receptor antagonist (Il36rn−/−) and the IL-36 receptor (Il1rl2−/−). The gene discussed is IL1RL2; the disease is Other metabolic disease.