Compared with the shRNA control, knockdown of TRIM59 significantly inhibited p-STAT3 (Fig. 8d and Supplementary Fig. 14c), PIM1 mRNA expression (Fig. 8e and Supplementary Fig. 14d), glioma sphere formation (Fig. 8f), and tumorigenicity of intracranial xenografts (Fig. 8g, h), but increased mH2A1 protein levels (Fig. 8d and Supplementary Fig. 14c). Here, STAT3 is linked to central nervous system cancer.