Additionally, LN229 cells overexpressing exogenous EGFRvIII, a constitutively active EGFR mutant that is frequently found in clinical GBM tumors and drives glioma tumorigenicity2, had a higher amount of nuclear TRIM59 proteins than parental LN229 cells (Supplementary Fig. 1a, b). This evidence concerns the gene EGFR and central nervous system cancer.