Re-expression of shRNA-resistant TRIM59 WT or S308D mutant rescued p-STAT3 (Fig. 8d and Supplementary Fig. 14c), PIM1 mRNA expression (Fig. 8e and Supplementary Fig. 14d), glioma sphere formation (Fig. 8f), and tumorigenesis of intracranial xenografts (Fig. 8g, h), but inhibited mH2A1 protein levels (Fig. 8d and Supplementary Fig. 14c). Here, TRIM59 is linked to central nervous system cancer.