In the present study, we observed that curcumin increased the expression of DIC, DHC1, DLC-3 and decreased the expression of KIF (Figure 4A–4F), suggesting that curcumin promotes retrograde transport and inhibits antegrade transport of autophagosomes in AD model N2a/APP695swe cells. The gene discussed is DYNC1H1; the disease is Alzheimer disease.