TACR1 and chronic myelogenous leukemia, BCR-ABL1 positive: SP released by CML cells can also bind to NK-1R in endothelial cells of blood vessels in a paracrine manner, causing plasma extravasation and granulocyte infiltration (5), or can activate immune cells such as mast cells and neutrophils that express NK-1R (59), resulting in amplification of the inflammatory response.