Clinical observations suggest that phosphorylated CREB is aberrantly sequestered in hippocampal neurons in Alzheimer’s disease with generalized disruption of CREB-mediated signaling (Satoh et al., 2009), BDNF regulation of synaptic plasticity, and neurogenesis (Cunha et al., 2010; Hollands et al., 2016; Moreno-Jiménez et al., 2019). This evidence concerns the gene CREB1 and Alzheimer disease.