In addition, an Aldh2 haplotype (rs737280; rs968529; rs16941667; rs16941669; rs9971942) was associated to an increased PD risk in subjects who were exposed to high doses of ALDH-inhibiting compounds: metal-coordinating dithiocarbamates (i.e. maneb, ziram), imidazoles (i.e. benomyl, triflumizole), dicarboxymides (i.e. captan, folpet) and organochlorines (i.e. dieldrin). This evidence concerns the gene LDHA and Parkinson disease.