LRRK2 and Parkinson disease: Recently, a PD-linked mutant form of Leucine-rich repeat kinase 2 (LRRK2) G2019S has been shown to affect synaptic vesicles endocytosis in patient-derived dopaminergic neurons, leading to cytoplasmic accumulation of DA and related oxidized catechols, as well as increased levels of αSyn [94].