CD274 and hypothyroidism: Of the anti-PD1-related endocrinopathies thyroiditis is most frequently seen, causing hypothyroidism in approximately 6.0% and hyperthyroidism in 2.8% of anti-PD1/PD-L1 treated patients (though these data may not capture the proportion of patients transitioning from initial hyperthyroidism to hypothyroidism, which often occurs).