Of the anti-PD1-related endocrinopathies thyroiditis is most frequently seen, causing hypothyroidism in approximately 6.0% and hyperthyroidism in 2.8% of anti-PD1/PD-L1 treated patients (though these data may not capture the proportion of patients transitioning from initial hyperthyroidism to hypothyroidism, which often occurs). This evidence concerns the gene PDCD1 and endocrine system disorder.