IL-8 signaling is known to influence the TME and promote cancer progression by (a) inducing the angiogenic response of endothelial cells, (b) recruiting neutrophils and myeloid-derived suppressor cells (MDSCs) to the tumor bed, (c) facilitating the proliferation, survival, and migration of tumor cells, and (d) promoting epithelial-mesenchymal transition (EMT) [17–22]. Here, CXCL8 is linked to neoplasm.