To determine the underlying specific signalling involved in the pro-bone metastasis role of MAZ in PCa, we further examined the effects of MAZ on multiple well-documented bone metastasis-related signalling pathways, including the TGF-β [7], Wnt [8], NF-kB [9], EGFR [10], and Notch [11] signalling, using a luciferase reporter assay. The gene discussed is EGFR; the disease is posterior cortical atrophy.