CD274 and neoplasm: BGB-A333 is a fully humanized IgG1-variant monoclonal antibody that specifically target and binds to PD-L1, blocking interaction to its receptor, PD-1 on T cell, reversing T cell inactivation, and increases T cell expansion resulting in cytotoxic T cell-mediated antitumor immune response against PD-L1-expressing tumor cells [86].