AhR activation upregulates the mRNA expression of its target genes CYP1A1 and CYP1B1 and promotes invasion by upregulating the mRNA expression of MMP-1, MMP-2 and MMP-9 and downregulating the mRNA expression of E-cadherin in human RCC cell lines, including 786-O and ACHN [98]. The gene discussed is AHR; the disease is renal cell carcinoma.