NES and neoplasm: Immunohistochemistry results were as follows: CD34 for vascular tumors (+), CK (pan) for tumors of epithelial origin (−), CD31 for endothelial cells and tumor angiogenesis (−), Desmin for mesenchymal tissues origin (small quantity +), EMA for epithelial origin (weak +), Ki-67 for cell proliferation in tumours (+ 2%), S-100 for nervous tissue origin (−), SMA for tumors of smooth muscle origin (+), Nestin for nervous tissue origin (+), CgA for tumors of neuroendocrine cells origin (−), and Syn for tumors of neuroendocrine cells origin (+) (Fig. 4, Additional file 1: Figure S1).